Sweet oranges, such as navel and Valencia, do not contain furanocoumarins. These include Seville oranges (often used in marmalade), limes and tangelos, a cross between tangerines and grapefruit. In all such cases there are alternative medications available that will not interact with grapefruit and the other citrus fruits that contain furanocoumarins, the culprit behind the "grapefruit juice effect," Derendorf says.
"For other drugs such as the antihistamine fexofenadine (Allegra), grapefruit juice blocks the uptake into the bloodstream and the concentrations in blood will go down." An example is the lipid-lowering drug simvastatin (Zocor)," says Derendorf. "If the drug is metabolized in the gut wall to a large extent and this metabolism is blocked, then the concentrations in the blood will go up. Derendorf was not involved in the Canadian review. It's been known for some time that grapefruit juice can "both increase or decrease the absorption of a small number of drugs," says Hartmut Derendorf, chairman of pharmaceutics at the University of Florida College of Pharmacy. Even some licorice can reduce the effects of certain blood pressure drugs and diuretics.Ī recently published review in the Canadian Medical Association Journal that found an increasing number of prescription drugs could have potentially dangerous interactions with grapefruit and grapefruit juice highlights the importance of consumers being aware of possible food and drug interactions. And eating large quantities of chocolate while taking some antidepressants can cause a sharp rise in blood pressure. Milk and other calcium products, for example, can block the absorption of certain antibiotics. But attention to medical labels, and not your taste buds, is needed when combining certain foods with medications. From milk and cookies to chocolate and peanut butter, some foods make a tasty combination.
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